Expanded Genetic Disease Testing
Genetic carrier testing has quickly become more advanced and now routinely offers information on hundreds of diseases. As the only sperm bank with a Medical Director who is a MD, PhD Geneticist, Fairfax Cryobank understands the value of this expanded genetic carrier disease testing.
Starting in January 2018, all new donors are being tested for an expanded genetic disease panel, including over 280 diseases. A donor’s Genetic Testing Summary is available online on his donor page. It lists all the genetic diseases he has been tested for and the results. To find the donors with expanded genetic disease testing, you can select for them on the Donor Search by going to the 'Genetic Testing Search' tab.
Many women have already had an expanded panel of genetic diseases tested as part of their pre-pregnancy work–up. Upwards of 70% will find they are a carrier for 1 or more genetic diseases. For clients who are carriers of a genetic disease, this additional testing in our donors means there is likely a suitable match they can select immediately. By using the 'Select by Genetic Disease(s) Tested Negative' or the 'Select by Gene(s) Tested Negative' on the donor search, finding a list of donors who are a suitable match is easy.
In fact, we are all carriers of several genetic disease mutations, only some of which can be tested for with today's technology. As carriers, we are expected to stay healthy. Before having children, if one person is a known carrier of a recessive genetic disease, we ideally want to know the partner’s carrier status for the same disease gene. Two people who are both carriers for the same recessive genetic diseases have a 25% chance of an affected child. (see image below). If both parents are tested negative for the same gene, or if only one is a carrier after testing, they are considered to be at low risk.
How do I know if a donor is a carrier of a genetic disease?
The donor's webpage will have an Acknowledgement of Genetic Risk form which gives specific details about his carrier results. Donors with expanded genetic testing who do not have an Acknowledgement of Genetic Risk form were not positive for any of the genetic diseases tested. His Genetic Testing, a PDF download on the donor's webpage, also gives full details of his genetic testing results.
I am considering a donor who is a carrier of a genetic disease. How does this affect me?
A donor who is a carrier of a genetic disease can be used successfully to have a healthy child. If you have been tested and your results show you are at reduced risk (negative) for the same disease the donor is a carrier of, then you can consider selecting this donor. If you have not had the testing completed, we recommend you do so before using this donor. Your physician or genetic counselor are good resources to help get any recommended testing completed and answer your questions.
What do I need to do if I want to use a donor who is a carrier?
1. Review the Acknowledgement of Genetic Risk form for the donor you wish to use. The Acknowledgement of Genetic Risk form is available as a downloadable PDF on the donor webpage in the donor search. It is also available as a DocuSign which allows a digital signature.
2. If indicated, consider genetic carrier testing, where a negative result for the same disease gene reduces risk.
3. When you are ready to move forward, sign and return the Acknowledgement of Genetic Risk form for your selected donor. This must be completed before shipping vials to your clinic.
4. Your clinic will receive a copy of your signed Acknowledgement of Genetic Risk form and a copy of the donor’s Genetic Testing Summary with your vial shipment.
Please call Client Services at 1800-338-8407 for assistance.
For more information see It Is Time to Consider Expanded Genetic Carrier Testing for All Gamete Donors